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A reportedly synthesized ligand, N-methyl-omethoxybenzohydroxamic acid (Nmombha), and its freshly prepared transition metal (Iron, Cobalt, Nickel, and Zinc) complexes have been synthesized. For characterization of reportedly synthesized ligand and its freshly prepared coordination compounds, spectroscopic techniques like Fourier transform infrared and ultraviolet/visible spectroscopy have been used. Spectroscopic studies show that the ligand acts as a bidentate chelate which forms a ring-like structure. The coordination of synthesized ligand with transition metals is via O, O donor sites, and it forms a fivemembered chelating ring on complex formation. Antimicrobial activities such as antibacterial and antifungal activities have been done for the said ligand and its complexes. Antibacterial activity of the synthesized ligand and its metal complexes are examined against four different species of Gram-positive and Gram-negative bacterial strains including Staphylococcusaureus, Klebsieludla, Esherichia coli, and Pseudomonas. Comparing the antibacterial effectiveness, the metal complexes having greater lipophilicity character show much higher antibacterial efficiency when compared with the free ligand. Cytotoxicity evaluation of the compounds shows that some of the samples are highly cytotoxic.

pure and applied biology

Synthesis, spectroscopic characterization and antimicrobial activities of N-methyl-o- methoxybenzohydroxamic acid and its metal (Fe, Co, Ni, Zn) complexes