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SUMMARY 1) A new procedur e for serum lipase determinations is presented. It is specific and sensitive. The incubation period is only 1 hour. 2) This method was clinically applied to some patients with a cute pancre a titis and was found to be more useful than other commonly performed pancreatic function tes ts. 3) Serum lipase activity was determined in the patients with liver diseases consisting of acute hepatitis, chronic hepatitis, liver cirrhosis and hepatoma, and with biliary diseases. Serum lipase level was elevated in many of them . 4) In order to determine the mechanism of the hyperlipasemia, several inves tigations were performed. It was concluded that hyperlipasemia in patients w.ith hepat ic diseases might be due to abnormal pancreas function influenced by liver impairments .

A new method for serum lipase determination and serum lipase activity in liver diseases determined by this method.