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Many problems are left unsolved on the exocrine pancreas. Pancreatic secretion is controlled by various factors while maintaining close relations with neighbouring organs. From the view point that the stomach and the pancreas are closely associated by way of gastrointestinal hormones, the factors involved in the mechanism of pancreatic secretion were investigated experimentally and clinically by using a gastrin related substance and serotonin. In the scantiness on the electrolyte changes in the pancreatic secretion, some observations were carried out on the electrolyte metabolism. Experiments with dogs and cats were performed under general anesthesia and pancreatic secretion was maintained by intravenous secretin injection. Clinical observations were carried out following ·pancreozymin-secretin combined test. Gastrin appeared to activate pancreatic secretion and serotonin to depress pancreatic juice flow. Neurogenic factors affecting pancreatic secretion were investigated after the administration of cholinergic and anticholinergic agents. The ecbolic action was activated by the former and the hydrelatic action was inhibited mainly by the latter. The effects on the pancreatic secretion of two diuretics, acetazolamide and furosemide, were also observed. The depression of pancreatic juice flow with little change of electrolytes was demonstrated.

Some physiological observations on the exocrine pancreas. The effects of some agents on pancreatic secretion.