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Aims and Objectives is 1.To know the epidemiology and intervention of sickle cell anaemia. 2. Correlation of clinical findings, haematological parameters, peripheral blood picture, sickling test and HB electrophoresis. Material and Methods: We conducted a prospective observational study of 175 cases of anaemia with SCD children to know the epidemiology of sickle cell anaemia. Data collected from case files, patient history, clinical profile, Peripheral blood findings, haematological parameters, sickling tests and HB electrophoresis reports. Results: Prevalence of SCD in this area is 8.57 %. Incidence in tribal is 67 %. Patient ages ranged from 2 to 14 years (median 6 years) at the time of recruitment. The age at first diagnosis of SCD was 2 years in our study. 8 patients (53.33 %) were male and 7 patients (46.66 %) were female. Maximum no. of cases present with symptoms of pallor (100%) followed by fever (33.33 %), abdominal pain (26.66%), chest and joint pain (20 %) & cough & difficulty in breathing (20 %) and skin infection (6.66 %) were found. 9 out of 15 patients (60 %) had clinically detectable splenomegaly and 4 (26.66 %) had hepatomegaly. Severe anaemia 6.66 %, moderate anaemia 40 % and mild anaemia 53.33 % with male predominance. Laboratory parameters showed a haemolytic profile. Conclusion: Proper and adequate counselling should be given to couple before marriage and haemoglobin genetic counselling and education should be included.

Epidemiology and Interventions of Sickle Cell Anaemia among Children in East Madhya Pradesh