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Bacterial resistance to the most commonly used drug ceftriaxone and its adverse effects have increased due to its injudicial use. Drug Utilization Evaluation (DUE) is an ongoing, systematic process designed to promote the appropriate and effective use of drugs. The purpose was to detect potential problems and search out solution. Methods: Data were collected in structured preform specific for DUE and were represented as numbers and percentages. For comparing numerical data, Mann–Whitney U-test was used as the data were non-parametric in distribution for ages and BMI, while Fisher exact test was used for categorical data comparison. Multivariate multi-logistic regression models to study the overlapped effect of the variables in development of Ceftriaxone induced liver functions derangement. Data were processed and analyzed using SPSS16 for statistical analysis.  Significance was considered as P < 0.05. Results: Our study showed that ceftriaxone use was more. High dose was used and for more than 10 days were the result of adverse effects and liver insult. Conclusion There is need for awareness among the general practitioners and clinicians to ensure rational use of antibiotics. This will minimize bacterial resistance to drug, adverse effects and save national economy. Keywords: Ceftriaxone, Drug utilization evaluation

Ceftriaxone Drug Utilization Evaluation (DUE) at Prince Abdulaziz Bin Moussae’ed Hospital, Arar, Kingdom of Saudi Arabia