English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Tuberculosis is still an important hygienic problem in developing countries (1). XDR bacilli are not only resistant to isoniazid and rifampin but also to fluoroquinolones and at least one of the three injectable drugs of amikacin, kanamycin and capreomycin (second line tuberculosis drugs) (2). Kanamycin and amikacin are indeed attached to 16S rRNA component of 30S subunit which leads to wrong coding of genetic transcription and therefore increase the level of mis-folded proteins in the cell that leads to cell death (3, 4). Mutations in cordons 1401 and 1402 of rrs gene lead to resistance to the aforementioned drugs. In the present work, the sequencing method was used to examine the mutations causing resistance to injectable drugs. In this descriptive study, a total number of 41 samples, including 23 resistant and 18 susceptible samples from isolates with phenotypically confirmed resistance to injectable drugs of kanamycin and amikacin were obtained from genome bank of Infectious Diseases Research Center (IDRC) of Arak University of Medical Sciences. The desirable amplicon containing mutant and wild-type codons were amplified using specific primers. The primers were designed with different specific software. Performing PCR on rrs gene (NC_000962.3) on the entire studied sam-

Correlation between phenotypic and genotypic drug resistance to kanamycin and amikacin in clinical isolates of Mycobacterium tuberculosis