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besity and insulin resistance are important pathogenic factors for type 2diabetes. Adipose tissue (AT) has been considered not only to be an energy storage but also a secretory organ releasing cytokines and hormones (1). In obesity, O 1. Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2. Department of Genetics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. 3. Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Metformin and Pioglitazone Reduce Gene Expression of Inflammatory Factors in Insulin Resistant and Hypertrophied Adipocytes