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Objective: to evaluate the effectiveness of high-fluoride dentifrice in decreasing the process of enamel demineralization. Material and Methods: thirty samples of bovine enamel were confectioned, sanded, polished and tested for determining their initial Knoop hardness. The samples were randomly divided into 3 groups: PD – Placebo Dentifrice, CD – Conventional Dentifrice (1450 ppmF) and HFD – High-Fluoride Dentifrice (5000 ppmF). To evaluate the dynamic process of demineralization, each group was subjected to pH cycling with demineralizing and remineralizing solutions. The samples were immersed for 6 and 18 hours respectively in those solutions for 5 days at 98.6oF. The dentifrice corresponding to each group was diluted (1:3) and the samples were treated for 1 minute, twice a day. After cycling, a final microhardness analysis was performed, using ANOVA and Tukey's test (p<0.05). Results: the results showed that the hardness of the final HFD (247.4±39.4) compared to CD (211.9±53.5) showed no statistical difference (p≤0.05). Conclusion: according to the results, it can be suggested that the high concentration of fluoride in dentifrice exhibited superior results in inhibition of enamel demineralization process than conventional dentifrice.

Effect of High-Fluoride Dentifrice on the Enamel Demineralization Related in Concern to Microhardness