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This study was an active, prospective surveillance study of adults 18 years and older hospitalized with community-acquired pneumonia (CAP) due to Streptococcus pneumoniae conducted at 21 hospitals in ten cities across the United States. This report describes the surveillance methodology applied between October 7, 2013 and September 30, 2016, including the identification and description of surveillance areas and populations at-risk for CAP hospitalization for estimation of incidence rates for selected study sites. *Correspondence To: Ronika Alexander Work: Address: Pfizer Inc. 500 Arcola Road, 5th Floor Bldg D Collegeville, PA 19426 Work Email: mailto:Ronika.Alexander@pfizer.com 35 ULJRI Vol 1, (4) 2017 STUDY PROTOCOL

the university of louisville journal of respiratory infections

Rationale and Methods of the Study Protocol: Streptococcus pneumoniae Serotypes in Adults 18 Years and Older with Radiographically-Confirmed Community-Acquired Pneumonia (CAP)