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espanolHelicobacter pylori es una bacteria que infecta la mucosa gastrica de alrededor de la mitad de la poblacion mundial y esta involucrada en la patogenesis de un gran numero de enfermedades gastricas y extragastricas en el huesped. Varios antigenos, adyuvantes y rutas de inmunizacion han sido evaluados buscando una vacuna que ayude a prevenir o erradicar la infeccion, consiguiendose diferentes grados de exito, si bien la inmunidad esterilizante solo se ha conseguido en algunos modelos animales. Varios mecanismos se han propuesto para explicar los resultados obtenidos con las vacunas potenciales evaluadas y para explicar como esta bacteria elude la respuesta inmune inducida por ella misma o por intentos de inmunizacion. El panorama hasta el momento, si bien no parece sencillo, no deja de ser esperanzador por los favorables resultados que vendrian tras la obtencion de una vacuna eficaz y por algunos estudios que motivan a la posibilidad de su consecucion. MED.UIS. 2017;30(3):111-20. EnglishHelicobacter pylori is a bacteria that infects the gastric mucosa of around half of the world’s population and it’s implicated in the pathogenesis of various gastric and extragastric diseases in the infected host. Several antigens, adyuvants and routes of immunization have been tested in order to find a vaccine that helps in the control of this bacteria, with varying degrees of success so far, however, sterilizing immunity has been achieved only in animals. Various mechanisms have been proposed to explain the outcomes obtained by testing the potential vaccines and to understand how this bacteria avoids the immunity triggered by itself or by the vaccines tested so far. The current picture does not seem easy but it’s still encouraging since some studies have given hope to the possibility of achieving an effective vaccine. MED.UIS. 2017;30(3):111-20.

Avances en la búsqueda de la vacuna contra Helicobacter pylori