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: aminoglycoside and quinolone resistance is serious problem for the treatment of infections worldwide.Without doubtone of the factors that has contribute  to the increase in the resistance in enterobacteria, is the great plasticity that possess the bacteria of this family to acquire genes that confers resistance to antimicrobials. Objective: to determine the patterns of resistance to aminoglycosides and quinolones in strains of Klebsiella pneumoniae isolated from two intensive care units of the Universidad de losAndes, Merida, Venezuela. Methods: weevalvated with 39 K. pneumoniae strains isolated in neonatal high risk unit and adult intensive care unit. Antibiotic susceptibility was tested by the disk diffusion method and by the E-test method. Detection of aac (3)-IIa, aac (6)-Ib, arma, rmt, qnrA, qnrS qnrB genes was carried out by PCR and subsequently sequenced. Results: 100 % of the strains isolated in 2007 were carriers of the gene aac(6)-Ib , while 57% of the strains isolated from the same uni  and the in the year 2009 were carriers of resistancet genes aac(3)-IIa, aac(6)-Ib. The resistance to quinolones were observed in the 88.8% of the strains of Klebsiella isolated from the AICU and were carriers the qnrB gene. Conclusions: the resistance to aminoglycosides in strains isolated in the neonatal high risk unit was mediated by genes aac(3)-IIa and aac(6)-Ib. While the resistance to quinolones was presented in the strains isolated from the adult intensive care unit mediated by the qnrB gene. MED.UIS. 2016;29(2):21-30.Keywords: Klebsiella pneumoniae. R Factors. Quinolones. Drug Resistance

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Resistencia a aminoglucósidos y quinolonas en cepas de Klebsiella pneumoniae aisladas en dos unidades de cuidados intensivos del Hospital Universitario de Los Andes Mérida, Venezuela, entre 2007 y 2009