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Blood safety comprises provisions of safe, adequate and quality blood and its componentsto the needy patients. Blood transfusion is a double edge sword which involves life saving of patients andalso subjected to risk of transfusion transmissible infections such as HIV, HBV, HCV, syphilis etc. Thisrisk has been reduced dramatically by routine screening of blood donors .Objective: To study the serological prevalence of transfusion transmissible infections among donors andto find any correlation between these infections and blood groups.Materials and Methods : This study was conducted for a period of three years (JAN 2016- DEC2018),carried out in blood bank of Basaveshwara Teaching and General Hospital, Kalaburagi in North Karnataka.A total of 13249 donors were analysed for transfusion transmitted infections.Results: Total of 13249 donors were screened during the study period and 253 donors were foundseropositive for transfusion transmissible infections (1.88%). In which, maximum 237 donors were positivefor HBV (1.78%), followed by 12 with HIV(0.090%), 3 with malaria (0.022%) and 1 with HCV (0.0079%)respectively. Seropositive for HBV was more common in B blood group donors, while HIV+ was maximumin A blood group donors and only 1 case of HCV was seen in AB blood group.Conclusion: The results of this study are comparable to various other studies done in India. There wasno significant association between various blood group antigens and 2 transfusion transmissible infections.Voluntary donations are safer as compared to replacement ones and should be encouraged. Efforts shouldme made to increase the awareness regarding voluntary blood donation in the local population.Keywords: Blood donors, Transfusion transmissible infections, Seropositivity.

Study of transfusion transmissible infections in donors in a tertiary care hospital in North Karnataka region