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Aim: To study the frequency of HER2/neu overexpression in esophageal, gastric, small intestine andcolorectal adenocarcinomas, to study the association of HER2/ neu overexpression with histopathologicaldifferentiation of esophagus, stomach, small intestine and colorectal adenocarcinomas and identifying itssignificance.Materials and Methods: Cross sectional study was performed on 70 cases which include resectedspecimens of stomach, small intestine and colorectal adenocarcinoma and biopsies of esophagus and theseorgans. The samples were divided into Group A (Esophagus and stomach) and Group B (Small intestineand colorectal). The samples were grossed and processed in the pathology department, and sections werestained with hematoxylin and eosin stain for histopathological confirmation of malignancy and gradedas well-differentiated (gradeI), moderately-differentiated (grade II) and poorly-differentiated (gradeIII )adenocarcinomas. The confirmed samples were processed for immunomarker study of HER2/ neu.Results: Over expression of HER2/ neu was found in 17(24.3 %) patients overall. Out of 17 HER2/neu positive cases, 4(26.7%) were from group a, while 13(23.6%) were from group b. No staining ormembrane staining in score “0” and considered negative for HER2/ neu overexpression. Faint/barely perceptible membranousstaining in 10% of tumors cells were observed in 5 (7.1 %) patie nts, which were labeled as score“1” and considered negative. Weak to moderate complete, basolateral or lateral membranous staining in 10% tumor cells were observed in 2(2.9%) patients, which were labeled as score “2” and consideredequivocal. Strong complete, basolateral or lateral membranous staining in 10% of tumors cells wereobserved in 17(24.3%) patients, which were labeled as score “3” and considered positive. Out of 70patients, 37(52.9%) were suffering from grade-II malignancy, 17 (24.3 %) from grade- I and 16 (22.8%)from grade-III. According to histologic

Frequency of HER2/neu over expression in adenocarcinoma of the gastrointestinal system, a Study of 70 cases