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Background: Metabolic syndrome is constellation of many different disorders. The common conditionsassociated with metabolic syndrome are obesity, hypertension, dyslipidemia and insulin resistance. Theseconditions do play some role in developing cardiovascular disease beyond traditional risk. Metabolicsyndrome have been commonly seen in patients of many skin diseases including psoriasis, lichen planus,acne inversa and even in skin malignancies. In chroni skin disorder and even in metabolic syndrome chronicinflammation has been shown to play some role in the pathogenesis of disease. The present study isdesigned with a view to know any association between skin diseases especially psoriasis and metabolicsyndrome, as well as expression of C-reactive protein in psoriasis and other skin diseases in this region.Materials and Methods: Present study was conducted on 76 histopathologically confirmed cases ofPsoariasis & Lichen Planus and 70 age and sex matched controls with skin lesions other than psoriasisand lichen planus. For metabolic syndrome criteria proposed by National cholesterol education programme(NCEP) ATP III was used. Triglycerides, HDL cholesterol, Blood sugar and CRP level was quantitativelydetermined on serum/plasma of patients. Chi square test and SPSS 19.0 software was used for statisticalanalysis.Results: Among psoriasis patients 18/52 had metabolic syndrome while this figure was low in lichenplanus patients 7/24. The incidence of metabolic syndrome with skin disease was high as comparedto control population and it was also statistically significant. Cases (psoriasis and lichen planus) withmetabolic syndrome had high CRP value 61.1% (11/18) and 57.1% (04/07) respectively as compared tocontrol 12.8% (09/71) and also displayed significant association.Conclusion: It was concluded from this study that metabolic syndrome is an important co-morbidity withpsoriasis and lichen planus which requires screening to avoid complications in later life.

indian journal of pathology and oncology

Prevalence of metabolic syndrome among psoriasis and lichen planus patients attending tertiary care hospital in Bundelkhand region: A prospective study