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Objectives: Histopathological examination of lymph node is one of the gold standard test for the diagnosis of neoplastic and non-neoplastic lesions, as lymphadenopathy is a common presentation of large variety of disorders including benign and malignant. This study aims at identifying various histopathological lesions of lymph node, their patterns and frequency of occurrence. Materials and Methods: This retrospective study includes 70 histopathologically diagnosed cases of lymph node biopsies received by the department of pathology, Dr. B.R. Ambedkar Medical College, Bengaluru from Jan 2017 to Aug 2018. Lymph nodes sent along with known primary malignant resection specimens were excluded from the study. Results: Out of 70 cases, non-neoplastic lesions were more common comprising of 57 cases (81.5%) and neoplastic lesions were 13 cases (18.5%).Non-neoplastic lesions included tuberculous lymphadenitis 27cases (38.5%), non-specific reactive hyperplasia 25 cases (35.7%), specific reactive lymphadenitis 3 cases (4.2%) and other granulomatous lesions 2 cases(2.8%). Neoplastic lesions included metastasis 7 cases (10%), Hodgkin’s lymphoma 5 cases (7.1%) and non-Hodgkin’s lymphoma 1 case (1.4%). Conclusion: Non-neoplastic diseases were more common than neoplastic diseases. Among nonneoplastic, tuberculous lymphadenitis was the most common lesion and among neoplastic lesions, metastasis was more common. Introduction Lymph nodes are distinct, ovoid lymphoid structures, approximately 600 such structures are spreadout throughout the body and are mainly concentrated in cervical, axillary and inguinal regions in the periphery and along the mesentry and mediastinum internally. Normal immune response in the body leads to proliferation and expansion of cellular components of Lymphnode causing it’s enlargement. The resulting morphological pattern and degree of change in the architecture of lymph node depends on the causative stimulus and intensity of response. This manifests clinically as abnormal increase in number, size and consistency of lymph nodes termed as Lymphadenopathy. These enlarged nodes become clinically significant when they measure >1cm (cervical, axillary) and >1.5cm (inguinal lymph nodes). Peripheral lymph nodes, preferably cervical lymph nodes are more commonly biopsied as they are more likely to yield definitive diagnosis. Lymphadenopathy can be caused by a spectrum of etiology ranging from proliferative benign lesions to malignant neoplasms. Histopathological examination of lymph node biopsies has been the gold standard investigation for lymphadenopathy. It provides an early definitive diagnosis and plays a pivotal role in the clinical management. The aim of the study is to histopathological evaluate the spectrum of lymph node lesions presenting as lymphadenopathy. Materials and Methods This retrospective cross-sectional study of lymph node biopsies was conducted at Department of Pathology, Dr. B.R. Ambedkar Medical College, Bengaluru over a period of one and a half years from January 2017 to August 2018. A total of 70 lymph node biopsies were selected for histopathological evaluation. All peripheral and abdominal lymph nodes were included in the study except metastatic lymph nodes associated with known case of primary malignancies and lymph nodes that are a part of radical surgeries. All the histology slides of all the cases were reviewed and necessary data regarding age, sex, site of biopsy and other relevant clinical history was retrospectively collected. All the biopsies were previously fixed in 10% Neutral buffered formalin and processed with paraffin technique and stained with Haematoxylin and Eosin. Special stains like Periodic Acid Schiff and Stain for Acid Fast Bacilli were done whenever necessary. The lesions were broadly classified in to following groups. 1. Tuberculous and non-tuberculous granulomatous lymphadenopathy. 2. Specific and non-specific reactive Article Info Received: 11th February, 2019 Accepted: 16th March, 2019 Published Online: 9th August, 2019

Study of histopathological spectrum of diagnosis in lymph node biopsies in a tertiary care centre