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Introduction: Fine needle aspiration cytology (FNAC) is a rapid and an accurate technique in diagnosing the nature of the breast lesion. There are only few studies where correlation between FNAC and histology of malignant breast lesion have been done. Aim: To study the correlation between FNAC and histopathology in determining grade of the breast malignancy and also to find the correlation between above two techniques in diagnosing malignant breast lesions. Materials and Methods: In prospective single center study, we included 35 patients with malignant breast lesion whose FNAC and histopathology were available. The histopathogical grading was done by using Scarf bloom Richardson grading system and cytological grading was done by Robinson’s grading. Results: Out of the 35 patients included in the study, the concordance rate of cytopathological correlation in determining the grading of lesion was 85.7% (30 out of 35 cases) and the concordance rate in determining nature of the lesion was 94.3% (33 out of 35 cases) respectively. Conclusion: Even though FNAC has replaced histopathology in diagnosing the nature of breast lesion, histopathology still remains the gold standard in determining grade of the malignant breast lesion. Introduction Breast cancer is the most common cancer among women worldwide and second most common cancer among Indian women. Women presenting with breast lump can either have benign or malignant breast lesion. FNAC is a rapid and accurate method in diagnosing the nature of breast lesion. It is the most widely used tool both for diagnosing early breast cancer and in confirming the recurrence of breast cancer. National Cancer Institute has recommended that tumor grading should be mentioned in reporting of FNAC of breast cancer. This study was conducted to find the correlation between FNAC and histopathology in determining the grade of the breast cancer, as the data from India is limited. Materials and Methods Our study was a prospective single institute study conducted in a tertiary medical centre in South India between 2009 to 2012. Patients having palpable breast lesions were included in the study and those who were non cooperative or with non palpable lesions were excluded. Patients were subjected to clinical examination, briefed about the FNAC procedure and informed consent was taken. FNAC was performed with strict aseptic precautions using 23 gauge needle. Slides were immediately wet fixed in 95% alcohol for H&E stain and Papanicolaou’s stain. Air dried smears were prepared and stained with Giemsa. Cytological interpretation was done taking into consideration relevant clinical and radiological data. Whenever the biopsy of the same patient was received at the laboratory, it was routinely processed to obtain paraffin section which were stained by H&E. Histopathological study was done independently. Thirty five patients who underwent cytology and true cut biopsy/surgery were included in the study. Cytological grading was done by Robinson’s grading. Histopathological grading was done by using the ScarfBloom Richardson grading system. The findings were recorded in a proforma and results of cytological and histopathological studies were later correlated. The results of the study were calculated by using methology of Galen and Gambino for substantiating the correlation. The ethical approval was not taken for the study as the data was properly anonymised and informed consent was obtained at the time of original data collection. Results Out of 35 patients, 15 (42%) of our study population were in the age group between 50 to 60 years (Table 1). The youngest patient was 32 years old and the oldest patient was Article Info Received: 9th November, 2018 Accepted: 29th January, 2019 Published Online: 9th August, 2019

Cytopathological correlation of malignant breast lesion in determining grade of the tumor- An experience from tertiary care center from South India