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This study conducted at the department of Pathology, Govt. Medical College, Thiruvananthapuram aimed at studying the morphologic spectrum of Peripheral Neuroblastic tumors based on the International Neuroblastoma Pathology Committee (INPC) criteria. Materials and Methods: The study included all cases of Peripheral Neuroblastic tumors received in the Department of Pathology, Government Medical College, Thiruvananthapuram during the period January 2004 to December 2008. Resected specimens and Incisional biopsy specimen’s/ lymph nodes of size more than 2x2 cm were included as per INPC criteria. Specimens were grossly and histopathologically studied and classified. Immunohistochemical markers were used only for undifferentiated neuroblastoma. Results: Of 56 cases received, one incisional biopsy was rejected. Of the remaining 55, 37 were Neuroblastomas (67%), 8 Ganglioneuroblastomas (15%) and 10 Ganglioneuromas (18%). The predominant type of Neuroblastoma received was Differentiated 26 cases (70%). Among Ganglioneuroblastomas 50% were of the Nodular classical type and in Ganglioneuromas 100% were of the mature type. Conclusion: The morphological spectrum of Peripheral Neuroblastic tumors were analyzed in 55 cases which included 37 cases of Neuroblastomas, 8 Ganglioneuroblastomas and 10 Ganglioneuromas. Further subtyping based on the I.N.P.C classification showed Neuroblastomas26 Differentiating, 9 Poorly Differentiated and 2 Undifferentiated. Among the Ganglioneuroblastomas4 were Nodular Classical, 2 Variant and 2 Intermixed. All 10 Ganglioneuromas were mature. Introduction Morphologically, Peripheral neuroblastic tumors can range from undifferentiated truly malignant Neuroblastomas (NB), via Ganglioneuroblastomas (GNB) to well differentiated benign Ganglioneuromas (GN). As a family, neuroblastic tumors demonstrate certain characteristic features such as spontaneous or therapy-induced differentiation of primitive neuroblasts into mature elements, spontaneous tumor regression, and a wide range of clinical behavior and prognosis which often mirror the extent of histologic differentiation. This heterogeneous group of tumors do not lend themselves to a simple, readily reproducible morphologic classification of nosologic and prognostic significance. This could be because they do not have a widely accepted and widely used uniform terminology and criteria for designation of types and subtypes; and are often diagnosed on the basis of an incisional biopsy which maybe nonrepresentative. Furthermore the pathologist also has to take into consideration the well-established genetic prognostic markers. To date several classifications have been put forth for this group of tumors. The latest accepted pathologic classification is that based on the recommendations of the International Neuroblastoma Pathology Committee (INPC), 1999 and partly revised in 2003. The present study conducted at the Department of Pathology, Medical College, Thiruvananthapuram aims at studying the morphologic spectrum of Peripheral Neuroblastic tumors based on the INPC criteria. Materials and Methods This study included all cases of Peripheral Neuroblastic tumors received in the Department of Pathology, Government Medical College, Thiruvananthapuram during the 5year period January 2004 to December 2008. Specimens were categorized as 1. Resected specimens 2. Incisional Biopsy specimens / Lymph nodes Biopsy specimens of less than 2x2cm size were not included in the study as per the I.N.P.C guidelines. All the specimens received were fixed in 10% formalin. Article Info Received: 31th December, 2018 Accepted: 29th January, 2019 Published Online: 9th August, 2019

Morphologic spectrum of Peripheral Neuroblastic Tumors- A 5 year retrospective study at a tertiary care centre in South India