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Neonatal mortality is one of the major obstacle to achieve present days health goals of worldhealth organization & neonatal sepsis is important preventable causes behind neonatal mortality all overthe world. Analysis of etiology of neonatal sepsis and antimicrobial susceptibility pattern among isolateshelps in implementation of antimicrobial policy in NICU for rational empirical antibiotics.Aim and Objectives: This study was carried out to analyze etiology, the change in trends in bacteriologicalagents of neonatal sepsis & also studying antimicrobial susceptibility pattern in these different isolatesduring study period.Materials and Methods: This is a retrospective observational study. In this study all the records of bloodculture samples taken from suspected neonatal sepsis cases in NICU & which are received & processed inMicrobiology department are analyzed, during January 2017 to August 2019.Results: Total 400 blood culture reports were analyzed from 400 suspected neonatal sepsis cases, out ofthat 98 were pure growth indicating 24.50% culture positivity. In these cases of neonatal sepsis 57 weremale & 41 were female. These newborn with sepsis had risk factors like preterm neonates (55.10%) lowbirth weight (53.06%) & Birth asphyxia (31.63%). Though there was Year wise variation observed inetiological agents of neonatal sepsis Overall 77(78.57%) isolates were gram negative organism & The mostcommon etiological agent of neonatal sepsis was Pantoea Species (25 isolates) followed by Klebsiellaspecies (24 isolates). It was observed that against antimicrobial agent’s like ceftazidime, ceftazidimeclavunic acid, cefoperazone, piperacillin tazobactum, ampicillin & cefoperazone sulbactum gram negativeisolates showed marked resistance. While gram positive isolates showed resistance towards penicillin,cefoxitin, azithromycin & calirithromycin. High Mortality 25.51% was seen in culture proven cases ofneonatal sepsis.Conclusion: We observed

ip international journal of medical microbiology and tropical diseases/ip international journal of medical microbiology and tropical diseases

Etiological divergence and antimicrobial susceptibility pattern among culture proven cases of neonatal sepsis from a tertiary care teaching institute in a konkan region of Maharashtra