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Topicality. An increase in the incidence of malignant tumors  progressing against the background of various comorbid pathologies determines the need to study the mutual influence  of pathological processes using experimental modeling. Such  models, for example, can reproduce the tumor growth modified by the comorbid condition of diabetes mellitus, the incidence rate of which is now increasing exponentially. In this  case, a clear demonstration of changes in the structure of organs outside the zone of the primary tumor node, using data  on the direct growth of the tumor and the content of diabetes  markers therein and in the perifocal zone, can serve as an evidence-based argument for the implementation of the mechanism of modified tumor progression.  The aim of our research work is to assess the state of the histological structure of some internal organs (the kidneys, the  ovaries, the peritoneum) when modeling the main pathological  process in animals, the growth of Guerin’s carcinoma, against  the background of a comorbid state of experimental diabetes. Materials and methods. We used 32 outbred male and female rats weighing 180-220 g to reproduce the model of experimental diabetes by a single intraperitoneal injection of alloxan  at a dosage of 150 mg/kg of body weight. One week after the  production of persistent hyperglycemia in the range of 25.4±1.2  mmol/l, the animals were transplanted with Guerin’s carcinoma subcutaneously in the region of the right shoulder blade.  Upon expiration of 2 weeks, the animals were decapitated, and  the harvested organs were prepared according to the practice  stages of morphological preparation for staining sections with  hematoxylin-eosin, followed by morphological examination of  the structure with the use of the Leica DM LS2 microscope with  the Olympus optical. C-5050 Zoom video camera and the Morfotest software. Photographing was carried out with magnification x10, x40, x100.  Results. Our study of the morphological portrayal of the ovary,  the kidney, the visceral and parietal peritoneum bears witness  to the identity of the changes, consisting in a total metastatic  lesion and abnormal transformation of the normal structure of  all the studied organs only in the female rats, when modeling  the comorbid state of diabetes mellitus. At the same time, the  aggressive nature of the tumor progression was manifested in  the blood filling of the vessels and hemorrhage, followed by  the release of tumor cells, their settlement, the enhanced proliferation, the formation of strands and compaction of cell aggregations throughout the volume of the organ. Some gender  specific features of the tumor progression were noted, which  were found in the female rats along the path of active metastasizing in case of small primary tumors, and in the male rats  along the path of stimulating the growth of the primary focus  without metastasizing. It was revealed that these differences are  associated with different degrees of saturation of the tumor and  perifocal zone with glucose, and they are determined by the  state of the insulin/insulin-like growth factor (IGF) axis.  Conclusion. Morphological examination of the organs affected by metastatic Guerin’s carcinoma in the female rats with diabetes mellitus makes it possible to detect not only the synergy  of both pathological processes, but also a powerful pro-oncogenic effect of the comorbid state of diabetes in the implementation of the tumor growth program.

cardiometry

Relationship between comorbid pathology and tumor progression. Morphological portrayal of internal organs in modeling the growth of Guerin’s carcinoma under diabetic conditions