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The aim of this study was to investigate the relationship of metabolic and immunological disorders in acute  tetrachlomethane, ischemic and alcoholic liver damage modelled in adult Wistar male rats weighing 120-160 g.  After evaluation of metabolic and immunological parameters at the local and systemic levels, and correlation  analysis was used to establish the relationship between the dynamics of the indicators against the background  of experimental pathology models. The close correlation between the studied immune and metabolic parameters  recognized for the tetrachlomethane, ischemic and alcoholic liver damage shows the existing “tension” between  the indicators of immune and metabolic status. Such close correlation between the studied immunological and  metabolic parameters at the system and local levels can serve to assess the severity of the disease, its prognosis,  treatment effectiveness and preventive measures.

Relationship between metabolic and immunological disorders in experimental acute tetrachlomethane, ischemic and alcoholic liver disease