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Comparative analysis of expression of genes encoding enzymes of catecholamine catabolism (monoaminbe  oxidases A and B (MAO A and MAO B) and catechol-O-methyl transferase (COMT)) and renalase has been  carried out in tissues of normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR).  Among investigated tissues the highest level of mRNA of genes encoding key enzymes of catecholamine catabolism  (MAO A, MAO B, COMT) was found in the heart of WKY rats. In SHR the mRNA levels of these genes were lower  (p&lt;0.05-0.01), however, no similar changes were observed in the tissues studied in dependence of hypertension.  The relative mRNA levels of the studied genes normalized versus actin mRNA significantly varied. In heart and  kidney the relative level of COMT mRNA significantly exceeded the relative levels of both MAO A mRNA and  MAO B mRNA. In the brain differences in mRNAs of MAOA, MAOB, and COMT were less pronounced. However,  in all examined tissue the renalase mRNA level was much (at least 10-20-fold) lower than any other mRNA studied.  Taking into consideration known correlations between mRNAs and corresponding protein products reported  in the literature for many genes these results suggest that in the case of any catalytic scenarios proposed or even  proved for renalase this protein cannot contribute to catecholamine degradation. It is also unlikely that the products  of renalase reaction, b-NAD(P)+ and hydrogen peroxide, can exhibit a hypotensive effect due to low expression  of the renalase encoding gene.

Comparative analysis of expression of genes encoding enzymes of catecholamine catabolism and renalase in tissues of normotensive and hypertensive rats