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.. Drug-drug interaction (DDI) is a specific type of adverse event, which develops due to multiple regimen therapy, and that may lead to significant hospitalization and death. Clinical and economic impact of drug interactions are increasingly accredited as a chief concern in critical care. Potentiating effects of DDIs in intensive care units are far more critical due to complex medications regimen, high risk severely ill population and associated metabolic and physiological disturbances which can impede drug effects. Pharmacist contribution is classified as clarification of drug order, appropriate drug information provision, and advice for substitute treatment. A multidisciplinary approach is very necessary in developing a pharmacotherapeutic regimen designed to optimize patient outcome and minimize any potential dug drug interactions. This review encompasses the prevalence, categorization, significance in term of patient safety and prescription efficacy, clinical and economic burdens, national and international data comparisons related to drug-drug interactions.

the professional medical journal/the professional medical journal

DRUG-DRUG INTERACTION; FACTS AND COMPARISONS WITH NATIONAL AND INTERNATIONAL BENTCH MARKS. A THREAT MORE THAN A CHALLENGE FOR PATIENT SAFETY IN CLINICAL AND ECONOMIC SCENARIO