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.. Background: Postoperative nausea and vomiting is reduced if inj Dexamethasone is given preoperatively in patient undergoing Laparoscopic Cholecystectomy. The aim of this prospective randomized, controlled trial was to look into effectiveness of dexamethasone before surgery may improve nausea, vomiting after surgery in patients undergoing laparoscopic cholecystectomy. Study Design: Prospective randomized study. Setting: Department of Surgery, King Edward Medical University, Lahore Pakistan. Period: Nov 2010 to April 2012. Methods: 138 Patients with Laparoscopic Cholecystectomy were randomized to receive 08 mg Dexamethasone (n=66) or placebo (n=72) intravenously before surgery. Seven patients were excluded on account of already on steroid treatment due to various reason. Vomiting and nausea were seen in next 24 hours after operation. Dexamethasone has minimal side effect after single dose administration. Six patients (12%) has nausea and vomiting in treatment group while 26 (47%) in the control group (p<0.001). Patient having dexamethasone, five (10%) need antiemitics as compare to 24 (44%) of those receiving placebo (p<0.001). Conclusion: Single dose of Inj Dexamethasone given preoperatively reduce nausea and vomiting markedly in Laparoscopic Cholecystectomy and may be routinely used in Laparoscopic procedure.

PONV; DEXAMETHASONE EFFECT ON POST OPERATIVE NAUSEA AND VOMITING IN LAPAROSCOPIC CHOLECYSTECTOMY