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metastatic colorectal cancer (mCRC). In spite of the striking advances that have been made in the systemic treatment of mCRC, chemotherapy alone is rarely associated with long-term survival. Complete resection offers the greatest likelihood of prolonged survival for patients with isolated liver metastases from CRC; indeed, a review of data from the Memorial Sloan-Kettering Cancer Center suggests that the actual cure rate is at least 17% and potentially as high as 25%.

Pre-operative Targeted Therapies in Patients with Hepatic Colorectal Cancer Metastases—Bevacizumab versus Cetuximab