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Among the causes of stone formation in the urinary system, an important role belongs to the microbiome, which affects the stability of the colloidal system of urine. Understanding the level of microbial tension in the urine allows to use pathogenetic approaches both for prevention and for the relapses of stone formation. The study included 162 patients with recurrent urolithiasis, 12 patients underwent complex anti-relapse therapy after surgical treatment (or spontaneous discharge of concretions after litokinetic therapy). It was determined that along with the known factors, there is a violation of quantitative indicators of urine microbiota. An increase of the microbial load of urine leads to a violation of the structure of uromodulin (Tamm – Horsfall protein), which in turn determines the high frequency of recurrence of urinary lithogenesis. Thus, a comprehensive assessment of the urine microbiota and its impact on the state of uromodulin, lead to an improvement in the quality of urolithiasis metaphylaxis. In the complex of metaphylaxis and prevention of urolithiasis, it is advisable to use antimicrobial agents (uroseptics) not only to reduce the risk of infectious and inflammatory complications, but also to increase the stability of the colloidal properties of urine.

Microbial load of the urine in patients with recurrent urolithiasis and its correction