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as control (female and male) and test (female and male) groups (N = 10). The test groups received 15 mg/kg nandrolone decanoate by intra muscular (im) injection for 2 weeks, but control groups received the same volum of oil vehicle. At the end, animals were deeply anesthetized by diethyl ether, scarified and their blood samples were collected. Liver enzymes and lipoproteins were measured by usual methods. Obtained data were analyzed by SPSS-15, applying ANOVA and Tukey tests. Results were expressed as mean ± SD. Statistical difference was recognized significant by P ≤ 0.05. Results: Results showed that AST value in the test groups were significantly increased compared to those of the control groups. In addition, HDL and cholesterol values in female test group were significantly increased compared to those of male test group. Moreover, final weight, food, and water intake in all test groups were significantly increased compared to those of control groups. Conclusions: These results indicated that subacute administration of nandrolone decanoate alters liver enzymes, lipoprotein profile, final weight, food, and water intake in rats. The exact mechanism needs future studies.

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats