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Background: Magnetic resonance imaging (MRI) abnormalities isolated to the splenium of the corpus callosum represent a unique radiologic phenomenon. The differential diagnosis includes toxic/metabolic dysfunction, demyelinating disease, seizures, trauma, tumor, infection and vasospasm. Though vasospasm may occur in multiple settings, splenial lesions associated with vasospasm secondary to hemorrhagic pituitary apoplexy have not been well described.

Cerebral Vasospasm Manifesting as a Transient Lesion of the Splenium of the Corpus Callosum Secondary to Pituitary Apoplexy