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Gunumuzde yaygin olarak kullanilan feniramidol (Cabral®) kas gevsetici etki gosteren analjezik bir ilactir. Bu calismada amac feniramidol’un potansiyel mutajenik etkisinin Ames Salmonella/Mikrozom test sistemi ile saptanmasidir. Bu amacla mutajenik etkiyi belirlemek icin feniramidol’un ticari formu olan Cabral®’in 5 farkli dozu (0.1-1000 µg/plak) Salmonella typhimurium’un TA98 ve TA100 suslari ile muamele edilmistir. Elde edilen bulgulara gore feniramidol’un denenen hicbir dozu TA98 ve TA100 suslarinda mutajenik etki gostermemistir.

Kas Gevşetici İlaç Feniramidol’ün Mutajenik Etkisinin Ames/Salmonella/Mikrozom Test Yöntemi İle Araştırılması