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In this paper, we present a new progressive multiple sequence alignment algorithm called Promalign. Our algorithm introduces the approached profile sequence a new definition of profile that aim to conserve similar residues in the alignment. The approached profile sequence is used to compute a new distance called approached profile distance. We present also a new score function between profiles and a new refinement algorithm. We assess our program Pro-malign on different datasets extracted from different benchmarks of protein sequences and we compare the scores obtained to other scores of the most efficient multiple sequence alignment programs.

Pro-malign: Multiple Sequence Alignment Algorithm using Approached Profile