Open AccessA Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
Author(s) -
G. Z. Yan,
C. N. Generaux,
M. Yoon,
R. B. Goldsmith,
R. R. Tidwell,
J. E. Hall,
C. A. Olson,
H. J. Clewell,
Kim Brouwer,
M. F. Paine
Publication year - 2012
Publication title -
carolina digital repository (university of north carolina at chapel hill)
Language(s) - English
DOI - 10.17615/j4jc-wg15
Subject(s) - prodrug , antiparasitic , active metabolite , pharmacokinetics , metabolite , pharmacology , antiparasitic agent , physiologically based pharmacokinetic modelling , chemistry , medicine , biochemistry , pathology