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| Organic solvents such as car fuel, which contains benzene and other solvents were known to cause skin irritation and contact dermatitis. Although anti-inflammatory steroids topical medications were used, they may result in side effects in susceptible persons. Herbal preparation was tried in literature. In the present study, Achillea fragrantissima, a wild plant in some areas of Saudi Arabia was used to speed slow-healing wounds. Thus, the study was designed to investigate its efficacy to treat experimentally induced benzene-dermatitis in mice skin. Twenty-five adult mice were shaved and animals were divided into GI as control and GII as benzene painted. The later was further divided into four subgroups; untreated, steroidal medicinal cream treated, a group treated with olive oil extract of Achillea (dried plant soaked in olive oil) and a group treated with olive oil only. Gross and histopathological observation were used to evaluate the treatment effects. Benzene painting produced skin hardening, scaling, epidermal hyperplasia and inflammatory reaction in skin dermis. Decrease in the hypodermal adipose tissue thickness was observed, those pathological changes were much improved or even absent in treated mice. Such results are similar to that observed in the group treated by medicinal cream. Achillea plant could be a source of future effective anti-dermatitis cream medicinal formulation against benzene-induced dermatitis. Olive oil extract of Achillea will be tested and compared to olive oil alone to prove the hypothesis.

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study