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Background:  Aspiration  of  serous cavities is  a  simple and  relatively  non-invasive  technique toachieve diagnosis. Cytological evaluation of body cavity fluid is diagnostically challenging. Especiallyin  malignant effusions, helps  in  staging, prognosis and  management of  the  patients. Aims:  Toassess the  utility  and  sensitivity  of  cell  block method over  conventional smear technique incytodiagnosis of  the  serous effusions. And  to  assess the  utility  and  sensitivity  of  cytologicalevaluation of body fluids with biochemical and clinical correlation. Methods: A total of 150 fluidspecimens were examined for conventional cytological smear (CS) and cell block method (CB). Outof 150 fluids, 96 were pleural fluid, 48 were ascitic fluid, 04 fluid from pouch of Douglas and 01 wasfrom synovial fluid. Results: In this study, the utility of the CB method in the cytodiagnosis ofmalignant effusions was found to be highly significant as compared to the CS method. The additionalyield of malignancy was 12% more as was obtained by the CB method. Conclusion: For the finalcytodiagnosis of body fluid, there is statistically significant difference between the two techniques. Inother words, CB  is  superior to  CS  method. It  gives  more information about the  architecturalarrangement and the likely source of primary. More important is that diagnostic material in cellblocks is available for special studies for Immunohistochemistry which can further supplement ourknowledge about the primary source of metastasis.

pathology update

Analysis of diagnostic value of cytological smear method versus cell block method in body fluids with clinical and biochemical correlation: study of 150 cases