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The present study demonstrates marijuana- and alcohol-induced impairment of a driving-relevant measure in a driving simulator task at (estimated) blood alcohol and THC concentrations that are below the per se cut-off for impaired driving in several states. The subject was an adult male with a history of occasional alcohol use (2-3 times/week for the past 6 months) and past but very infrequent use of marijuana, i.e., less than once/month for the past 6 months. The testing procedure was a crash avoidance test using a fixed base driving simulator. In this procedure, while driving at 55 mph, the subject was required to make an ‘emergency’ steering maneuver to avoid crashing into a ‘stalled car’ that appeared on the roadway immediately (40 meters) ahead. In the absence of any drug treatment, after training the subject effectively made this avoidance maneuver in >98% of trials (20 trials/session), with a crash avoidance response latency of approximately 450-475 msec from the onset of the car ahead until an abrupt crash avoidance steering response of >10 degrees.

journal of addiction medicine and therapeutic science

Marijuana and alcohol increase crash avoidance reaction time in a driving simulator test at blood concentrations below commonly-used per se ‘Cut-offs’ for Intoxication