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need for qualified personnel and sophisticated instrumentation to perform the assays. In contrast, as we have pointed out with regard to OC markers, biosensor technology provides the possibility for direct conversion of the presence (and concentration) of a marker into a sensor -generated electrical signal [3]. This type of device is capable of function in relatively small samples, in a flow-injection protocol, provision of rapid signal generation, inexpensive manner, and, importantly, multiplexed detection. It is envisaged that two distinct categories of application of these devices are available, that is their use in the central clinical biochemistry facility or in a point-of-care fashion. Clearly, cost-effective, general screening of sera in the former would be appropriate for employment of these sensors, especially given the usual robot-oriented, automated equipment available in such a facility.

Early Stage Screening for Ovarian Cancer: The Case for Biosensor Technology