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A novel series of 1-aryl-3,4-bis-(3-alkyl/phenyl-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazol)-1H-pyrazole (5a-i) are synthesized by the cyclocondensation of 1-(aryl)-1H-pyrazol-3,4-dicarboxylic acids with 3-alkyl/aryl-4-amino-5-mercapto-1,2,4-triazoles. Pyrazole dicarboxylic acids were prepared by the 1, 3-dipolar cyclo addition of 3-aryl sydnones with dimethylacetylenedicarboxylate (DMAD). The newly synthesized compounds were studied for their antibacterial, antifungal and antioxidant activities. Particularly compounds 5a and 5g showed considerable antibacterial activity against the standard drug, while all the tested compounds displayed poor inhibitory effect against fungi. Compound 5d exhibited good antioxidant activity. The docking study was performed with Acinetobacter baumannii penicillinbinding protein target using AutoDock 4.2, which proved H-bond interaction and strong binding affinity.

Synthesis, Antimicrobial, Antioxidant and Molecular Docking Study of Some Novel Bis-1, 2, 4-Triazolo [3, 4-b]-1, 3, 4-Thiadiazoles