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This study was carried out to investigate the healing potential of Costus afer stem juice extract on rat skin wound. Twenty-five (25) adult female albino rats weighing between 243-320g were used for the study. They were divided equally into 5 groups. The rats were aseptically wounded on their dorsum under ketamine hydrochloride anaesthesia. Immediately hemostasis was attained, the rats were treated according to their groups. Group A wounds were left without treatment, group B were treated only on the first day with iodine, group C were treated for 7 days with iodine ointment, group D were treated only on the first day with Costus afer stem juice extract, and group E were treated for 7 days with Costus afer stem juice extract. The rats were under observation for 35days within which complete healing was observed. The time taken for the wounds to heal was recorded in days for each animals and ANOVA analysis was carried out using SPSS v. 20. On complete healing, sections of the healed tissue were collected for H&E stain. During the healing process, it was observed that wounds treated with Costus afer stem juice extract maintained a moist wound environment without infection despite being open to the environment. The healing time was also found to be significantly small (p<0.05) in group D treated only on the first day with Costus afer stem juice extract. H&E sections showed randomly organized dermal fibres in group D and E treated with Costus afer stem juice extract. There was also indication of growing hair follicles in group D treated only on the first day with Costus afer stem. In conclusion, Costus afer stem juice extract maintained a moist wound environment with more favorable healing outcome than iodine treatment.

Investigating the Wound Healing Potential of Costus afer (Ker Gawl) Stem Juice on Cutaneous Wounds of Albino Rats