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Background: Bone diseases are common complications in HIV infected patients with increased fracture rates. Factors, calcium and Vitamin D deficiency, depression and smoking are contributed to increased prevalence of this disease. Some studies reported that antiretroviral therapy may also relate to bone diseases in HIV patients. Aim of the study: To assess plasma levels of bone metabolism biomarkers in HIV infected patients before and after ART treatment. Materials and methods: Leftover blood samples from advanced clinical monitoring project were used for this study. 156 individuals with HIV infection before and after ART at different stages of treatment (0, 6 and 12 months) were investigated. Plasma level of bone metabolism biomarkers like PTH, phosphate, Vitamin D and Osteocalcin were measured using Cobas 6000 chemistry machine. Data analysis was carried out by means of statistical package for social science version 16. Results: The mean level of PTH and Osteocalcin increased significantly in HIV infected patients taking ART compared to HIV patients not taking ART (p value<0.05). Viral load was negatively correlated with PTH, Osteocalcin, Vitamin D and Phosphate. Conclusions: As the duration of treatment with ART extended, further increase of the higher rate of bone turnover in HIVinfected patients was observed.

Assessment of Plasma Levels of Bone Metabolism Biomarkers among HIV Infected Adult Patients in Ethiopia