English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Recently, Mycobacterium tuberculosis (MTB) strains have transformed from about to be eradicated to most resistant microbe, thank to Multidrug resistant (MDR) and extremely drug resistant (XDR) MTB. Various novel approaches are being explored including antimutagen, efflux inhibitors etc which can act as adjuvant therapy. But there is still need to develop real anti-mycobacterial drug. This research reports small molecule anti-infectives which are specifically potent against several strains and isolates of TB. The hit compound 7f has also proved to be active against almost 25 clinical isolates comparable to marketed anti-TB agents.

Design, Synthesis and Evaluation of Linked Pyridinyl-Oxadiazoles as Treatment of XDR and MDR Tuberculosis-Part II