English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The aim of this study was to prepare sustained release bilayer tablet of Tolperisone HCl (TOL) and Diclofenac sodium (DFS) for the effective treatment of patient with acute musculoskeletal spasm or acute low back pain. TOL and DFS were formulated as both sustained release layer by using Methocel K100M. A hydrophilic matrix-based bilayer tablet using different contents of Methocel was developed using wet granulation technique to contain 450 mg of TOL and 100 mg of DFS. The effect of contents of hydrophilic matrix (Methocel) and channel forming agent (Lactose) on TOL release was studied. The dissolution study of sustained release layer showed that an increasing amount of Methocel results in reduced TOL release. The dissolution study of sustained release layer showed that an increasing amount of lactose results in increase TOL release. The inclusion of channel forming agent (Lactose) enhanced the release of TOL from sustained release layer. Thus sustained release bilayer tablets could be a potential dosage form for delivering TOL and DFS in a controlled release manner. Formulation containing 25 mg of Methocel K100 M (DFS) and 125 mg of Methocel K100 M (TOL) in both sustained release layer showed desired drug release. Bilayer tablet was suitable for preventing direct contact of these two drugs and thus to maximize the efficacy of combination of two drugs for patient with acute musculoskeletal spasm or acute low back pain.

Design and Development of Tolperisone Hcl and Diclofenac Sodium Sustained Release Tablet