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Cellular systems are often exposed to variations in their environment and, as a consequence, the cell systems have evolved a variety of pathways to promote cell survival during such challenges. Such “pro-survival” cellular pathways, often referred to as cellular stress response pathways, involve intricate cellular signalling networks, some of which are evolutionarily conserved. Given that such response mechanisms have cascading ef fects on the cellular physiology , it is not unexpected that regulatory forms of long non-coding RNAs (lncRNAs) play critical roles in these processes as well. This short review focuses on the regulatory roles of lncRNAs in transcriptional control during cellular stress response in higher vertebrates. Here, we elaborate on a few recent examples from the mammalian systems on the role of lncRNAs in the heat shock response process.

Role of the Two Highly Conserved Features of Initiator tRNAs in the Initiation of Proteins and Synthesis in Eubacteria