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The pioneering work of Grobstein, Saxen, and Sariola led to the development of culture systems that could support the growth and differentiation of mouse kidney rudiments in vitro .[1][1] Cultured kidney rudiments can be easily manipulated, either genetically or by the application of growth factors

Amniotic Fluid Stem Cells within Chimeric Kidney Rudiments Differentiate to Functional Podocytes after Transplantation into Mature Rat Kidneys