Open AccessCancer Clinical Trials—Do We Need a New Algorithm in the Age of Stratified Medicine?
Author(s) -
Doroshow James H.,
Sleijfer Stefan,
Stupp Roger,
Anderson Kenneth
Publication year - 2013
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2013-0190
Subject(s) - medicine , clinical trial , cancer , clinical oncology , precision medicine , underpinning , personalized medicine , medical physics , oncology , bioinformatics , data science , intensive care medicine , pathology , computer science , biology , civil engineering , engineering
The explosion in genomic discovery science and its application in oncology in recent years is underpinning an unprecedented increase in our understanding of mechanisms underlying malignant processes. An increased understanding creates challenges pertinent to the area of cancer clinical trial development and application. Although the existing cancer clinical trial algorithm has served us well in the past, is it still fit for purpose in the 21st century?