Open AccessDevelopment of Rational Drug Combinations with Investigational Targeted Agents
Author(s) -
Clark Adam,
Ellis Matthew,
Erlichman Charles,
Lutzker Stuart,
Zwiebel James
Publication year - 2010
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2009-0262
Subject(s) - medicine , investigational drugs , drug development , drug , pharmacology , drug approval , clinical trial , intensive care medicine
This manuscript explores specific examples and criteria in which an alternative regulatory process to the existing combination rule would be appropriate and feasible and thus could be adopted by developers.