Open AccessDevelopment of Farnesyl Transferase Inhibitors: A Review
Author(s) -
Appels Natalie M.G.M.,
Beijnen Jos H.,
Schellens Jan H.M.
Publication year - 2005
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.10-8-565
Subject(s) - drug discovery , mechanism (biology) , prenylation , mechanism of action , transferase , pharmacology , medicine , enzyme , computational biology , biology , in vitro , biochemistry , philosophy , epistemology
L earning O bjectives After completing this course, the reader will be able to: Describe the potential mechanisms by which farnesyl transferases inhibit tumor growth. Explain possible mechanisms by which tumor cells may develop resistance to this class of agents. Discuss the scientific requirements for developing targeted cancer treatments that will actually be useful in patients.Access and take the CME test online and receive 1 hour of AMA PRA category 1 credit at CME.TheOncologist.com