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Clozapine is underprescribed due to neutropenia risk. Blood tests every 3 months in those on continuous treatment for &gt; 1 year who have never had an absolute neutrophil count (ANC) &lt; 2,000/µL has been proposed as a monitoring strategy; however, there are no South American data to support this recommendation. This study sought to investigate whether clozapine use and other variables could explain the occurrence of ANC &lt; 1,000/µL in patients with severe mental disorders.

Risk of neutropenia among clozapine users and non-users: results from 5,847 patients