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Candida  species are the leading cause of invasive fungal infections, and over the past decade there has been an increased isolation of drug resistant  Candida  species. This study aimed to identify the species distribution of  Candida  isolates and to determine their unique antifungal susceptibility and resistance patterns. During a cross-sectional study, 209  Candida  isolates (recovered from 206 clinical samples) were collected and their species distribution was determined using ChromAgar  Candida . The Vitek-2 system (Biomerieux, South Africa) was used to determine minimum inhibitory concentrations (MICs) to azoles (fluconazole, voriconazole), echinocandins (caspofungin, micafungin), polyenes (amphotericin B) and flucytosine. Four species of  Candida  were isolated, of which  C. albicans  was the most frequent, isolated in 45.4% (95/209) of the isolates, followed by  C. glabrata : 31.1% (65/209). The MICs of the different antifungal drugs varied amongst the species of  Candida . From the 130 isolates tested for MICs, 90.77% (112/130) were susceptible to all antifungal drugs and 6.9% (9/130) of the isolates were multi-drug resistant.  C. dubliniensis  (n=2) isolates were susceptible to all the above mentioned antifungal drugs. There was no significant difference in species distribution amongst clinical specimens and between patients' genders (P>0.05). An increase in MIC values for fluconazole and flucytosine towards the resistance range was observed. To our knowledge, this is the first report on surveillance of  Candida  species distribution and antifungal susceptibility at a public tertiary teaching hospital in Eastern Cape, South Africa.

brazilian journal of medical and biological research

Species distribution and antifungal susceptibility patterns of Candida isolates from a public tertiary teaching hospital in the Eastern Cape Province, South Africa