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EnglishA deterioracao progressiva e perda da cartilagem articular sao os eventos finais da osteoartrite (OA). Especies reativas de oxigenio (ROS) tem papel importante na atividade catabolica de condrocitos, levando a morte celular e quebra dos componentes da matriz. Injecoes intra-articulares de corticosteroides, como com o acetonido de triancinolona, sao usadas para controle da dor e inflamacao associadas a OA. Novos tratamentos para a OA, como o plasma rico em plaquetas e o pentosano polissulfato sodico, tambem tem sido utilizados e necessitam de maiores investigacoes para determinar sua seguranca para as celulas articulares de equinos. Neste estudo in vitro, o uso destas tres substâncias (acetonido de triancinolona, pentosan polissulfato de sodio de plasma rico em plaquetas) em condrocitos saudaveis de equinos nao alterou o status antioxidante quando comparado aos grupos controle, indicando que puderam ser considerados seguros em condicoes saudaveis. portuguesProgressive deterioration and loss of articular cartilage are the final degenerative events common to osteoarthritis (OA). Reactive oxygen species (ROS) play an important role in this chondrocyte catabolic activity, leading to cell death and matrix components breakdown. Intra-articular corticosteroid injections such as triamcinolone acetonide have been used to control pain and inflammation associated with OA. New treatments for OA, platelet-rich plasma and pentosan polysulphate sodium have also been used and further investigations are necessary to determine their safety in joint cells. In this in vitro study, the use of these three substances (triamcinolone acetonide, platelet-rich plasma, and pentosan polysulphate sodium) in healthy chondrocytes did not alter the antioxidant status when compared to control groups, indicating that they could be considered safe in healthy conditions.

Can Triamcinolone acetonide, platelet-rich plasma, and pentosan polysulfate sodium induce oxidative stress in cultured equine chondrocytes?