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EnglishIn healthy cartilage, chondrocytes maintain an expression of collagens and proteoglycans and are sensitive to growth factors and cytokines that either enhance or reduce type II collagen synthesis. In osteoarthritis, pro-inflammatory cytokines, such as IL-6, induce overexpression of metalloproteinases (MMP) and decreasing synthesis of aggrecan. Use of chondroprotectors agents, such as Platelet-Rich Plasma (PRP) and triamcinolone (TA) are alternatives to reduce the progression of joint damage. In this study, we used chondrocytes extracted from metacarpophalangeal joints of healthy horses as the experimental model. Cells were treated in vitro with PRP or TA. No differences were observed between these treatments in comparison to the control group when the expressions of MMP9, MMP13, IL-6 and ACAN genes were evaluated (P portuguesNa cartilagem saudavel, os condrocitos mantem a expressao de colagenos e proteoglicanos, sendo sensiveis a fatores de crescimento e citocinas que aumentam ou reduzem a sintese de colageno tipo II. Na osteoartrite, citocinas pro-inflamatorias, como a IL-6, estimulam a expressao de metaloproteinases (MMP) e reduzem a sintese de agrecano. O uso de condroprotetores, como o Plasma Rico em Plaquetas (PRP) e triancinolona (TA) e uma alternativa para se reduzir a progressao do dano articular. Neste estudo foram usados condrocitos extraidos das articulacoes metacarpofalangeanas de equinos saudaveis. As celulas foram tratadas in vitro com TA ou PRP. Nao foram observadas diferencas entre os tratamentos comparando-se com o grupo controle quanto a expressao genetica de MMP-9, MMP-13, IL-6 e ACAN (p

ciência rural

Comparison of the effects of triamcinolone acetonide or platelet-rich plasma on expression of extracellular matrix-related genes in equine healthy chondrocytes in vitro