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Giardiasis is an infectious disease caused by  Giardia duodenalis . The pro-drug metronidazole (MTZ) is the first-line treatment for giardiasis. Parasite’s proteins as pyruvate:ferredoxin oxidoreductase (PFOR), ferredoxin (Fd), nitroreductase-1 (NR-1) and thioredoxin reductase (TrxR) participate in MTZ activation. Here, we showed  Giardia  trophozoites long-term exposed to MTZ presented higher IC 50  than controls, showing the drug influenced the parasite survival. That reduction in MTZ’s susceptibility does not seem to be related to mutations in the genes  pfor ,  fd ,  nr-1  or  trxr . It points that different mechanism as alterations in other metabolic pathways can account for  Giardia  resistance to MTZ therapy.

memórias do instituto oswaldo cruz

In vitro-induction of metronidazole-resistant Giardia duodenalis is not associated with nucleotide alterations in the genes involved in pro-drug activation