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espite so many genetic discoveries, ease for a genetic test and even exome se-quencing, it is almost impossible to conduct a diagnostic approach for hereditary neurological diseases without semiotic observations. The contemplative method of Osler and clinical observation of Charcot are lessons left for our generation, which are crucial elements for clinical diagnosis

Diagnosis at a first glance? "Bulging eyes" as a clue for a more accurate diagnosis in spinocerebellar ataxias